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Effect of Probiotics on Reversing Chronic Kidney Disease

CKD affects 15% of the U.S. adult population. In the United States, 30 million adults are estimated to have chronic kidney disease—and most aren’t aware of it. Here are some great Resources on Chronic Kidney Disease for Patients. This includes web links, journals, articles shared online. Most of them are from good journals and sources and others you will have to check the authenticity. This is to bring a compendium of what I read online about CKD. This might be helpful for many who are suffering from this disease and seeking information and resources to deal with this.

Resources on Chronic Kidney Disease for Patients

1. Natural Kidney Journey Diet to Reverse Kidney Damage - It is a Facebook group established to support CKD patients to deal with diet. It is a lifestyle which helped many people to increase their gfr.

2. How to Control Chronic Kidney Disease at Home - It is a post shared by someone who reversed the CKD. He kidney was more than 50% damaged and now she is having 90 gfr.

3. Role High Blood Pressure Medicine in Chronic Kidney Disease - A post on how ACS/ARBs reduce the chance of proteinuria in kidney patients.

4.  Proposal of remission criteria for IgA nephropathy - Article on Springer Link published on 04 August 2013 in Clinical and Experimental Nephrology titled as Proposal of remission criteria for IgA nephropathy authored by Yusuke Suzuki, Keiichi Matsuzaki, Hitoshi Suzuki, Naoko Sakamoto, Kensuke Joh, Tetsuya Kawamura, Yasuhiko Tomino & Seiichi Matsuo mention a standardized set of criteria for defining IgA nephropathy remission:

4.1. Three consecutive negative results over a 6-month period in urinary occult blood tests.
4.2. Urinary sediment red blood cell count of <5/high-power field (hematuria remission).
4.3. Urinary protein of <0.3 g/day (g/g Cr; proteinuria remission).
Clinical remission is defined as cases with both hematuria and proteinuria remission.

Increased gut permeability or leaky gut Remission

5. Increased gut permeability or leaky gut Remission - Article published on 2007 December in Neuro Endocrinol Letters titled as Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome authored by Maes M1, Coucke F, Leunis JC mention that treatment with specific antioxidants such as glutamine, N-acetylcysteine, gamma oryzanol and zinc and a "leaky gut diet" could achieve complete remission of the chronic fatigue syndrome (CFS) symptoms.

6. Zinc supplementation tightens "leaky gut" in Crohn's disease -  Article published on 2001 May in Inflamm Bowel Dis titled as Zinc supplementation tightens "leaky gut" in Crohn's disease. authored by Sturniolo GC1, Di Leo V, Ferronato A, D'Odorico A, D'Incà R. mention that patients received oral zinc sulfate supplements (110 mg three times a day) for 8 weeks and after 12 months follow up, it was foudn that zinc supplementation can resolve permeability alterations in patients with Crohn's disease in remission.

7. The gut as a source of inflammation in chronic kidney disease - The study states that gut focused therapeutic methods are needed to manage CKD.

8. Understanding Gut Health - This blog post try bring attention to many of the myths related to gut. How Candida was a myth and how Small intestinal bacterial overgrowth (SIBO) or anti biotic resistant strain streptococcus is what causing the issue. Candida or the friendly bacteria is eating food that could feed other toxic strains such as streptococcus, E. coli, Epstein-Barr, shingles, or any other harmful virus, bacteria, or toxin. Removing eggs, soy, gluten, corn, dairy products and grains from the diet and adding fruit will help starve the bacteria and reduce intestinal inflammation. Epstein-Barr or shingles symptoms, are incorrectly diagnosed with leaky-gut.

Resources on Chronic Kidney Disease for Patients

Minimized bile production in the liver due to constant stress, high fat or sugar foods cause low hydrochloric acid (which is a blend of seven acids)lead to rotting food. Rotting food produces ammonia and high amount of gas. Toxic bacteria feed on ammonia.

So you need to rebuild hydrochloric acid levels by drinking 16oz (4 or 8oz for starters) of celery juice every morning on an empty stomach, Aloe Water (Cut a 2-inch piece off the aloe leaf. scoop out the gel and place in a blender with 8-16oz water. Blend on high for 10-20 seconds. Pour in glass and drink immediately on an empty stomach), Papaya, eating avocado, boiled potato and a hot, cooked dish. Ginger, peppermint, licorice root, Goldenseal .

Antibiotics leave scar tissues ins stomach where they burn the hair type structures of the stomach. Study titled Recovery of gut microbiota of healthy adults following antibiotic exposure suggest that despite a mild yet long-lasting imprint following antibiotics exposure, the gut microbiota of healthy young adults are resilient to a short-term broad-spectrum antibiotics intervention and their antibiotics resistance gene carriage modulates their recovery processes. The gut microbiota of the subjects recovered to near-baseline composition within 1.5 months, although 9 common species, which were present in all subjects before the treatment, remained undetectable in most of the subjects after 180 days.

Toxic bacteria make nerve endings very sensitive making peristalsis hard. Never take canola oil (Kadukenna in malayalam) which wrecks havoc on the gut lining and exacerbates any intestinal tract issue. It is time to slow down ckd using scientific resources.

Probiotics, Synbiotics, Prebiotics and Chronic Kidney Disease for Patients

9. Effects of probiotic VSL#3 on glomerular filtration rate - Article published on 2017 December in Can Vet J. titled as Effects of probiotic VSL#3 on glomerular filtration rate in dogs affected by chronic kidney disease: A pilot study authored by Ilaria Lippi, Francesca Perondi, Gianila Ceccherini, Veronica Marchetti, and Grazia Guidi mention that VSL#3 supplementation seemed to be efficient in reducing deterioration of GFR over time in dogs affected by CKD.

10. Synbiotics Lowered PCS

Synbiotics are dietary supplements combining probiotics and prebiotics. In another study titled Probiotic Soy Milk Consumption and Renal Function Among Type 2 Diabetic Patients with Nephropathy: a Randomized Controlled Clinical Trial , it was confirmed that intake of probiotic soy milk or fortified soy milk with Lactobacillus plantarum A7 may have a beneficial effect on the renal function in patients with Diabetic Nephropathy.

Another study titled Kidney Function Improvement by Soy Milk Containing Lactobacillus plantarum A7 in Type 2 Diabetic Patients With Nephropathy: a Double-Blinded Randomized Controlled Trial mention that soy milk containing Lactobacillus plantarum A7 were given for 8 weeks to experiment group and normal soy milk to control group. The results were significant reduction in albuminuria (P = .03), serum creatinine (P < .001), serum interleukin-18 (P = .002), and serum sialic acid (P = .001) compared with conventional soy milk. Probiotic soymilk supplementation also led to a significant improvement in estimated glomerular filtration rate (15.9 ± 10.8 mL/min versus 3.2 ± 8.4 mL/min, P < .001) compared with the control group. Probiotic soy milk was safe and well-tolerated by patients with diabetic nephropathy for 8 weeks. Probiotic soy milk also improved indexes of kidney function in type 2 diabetic patients with nephropathy.

11. Probiotics lowered PCS

In another study based on the databases of Pubmed, EMBASE and Cochrane Library (No. CRD42018093080) titled Efficacy of Probiotics Supplementation On Chronic Kidney Disease: a Systematic Review and Meta-Analysis, found that Probiotics supplementation may reduce the levels of p-Cresyl sulphate (PCS) and elevate the levels of IL-6 whereby protecting the intestinal epithelial barrier of patients with CKD. It mention eight studies with 261 patients at CKD stage 3 to 5 with and without dialysis were included that was conducted in recent years. Another study The effects of probiotics on renal function and uremic toxins in patients with chronic kidney disease; a meta-analysis of randomized controlled trials confirm this result.

Another study titled Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial mention that In patients with CKD, synbiotics did not significantly reduce serum IS but did decrease serum PCS and favorably modified the stool microbiome.

12. Probiotics increase in UA and a decrease in urea and BUN 

The databases from July 1967 through to March 2016 in MEDLINE, Scopus, and Google Scholar was used. Of 437 studies, 13 were eligible for inclusion in the meta-analysis. This study titled The effects of prebiotic, probiotic, and synbiotic supplementation on blood parameters of renal function: A systematic review and meta-analysis of clinical trials showed a significant increase in UA and a decrease in urea and BUN. The review suggested that large-scale, well-designed randomized controlled trials needs to be done to prove the safety and efficacy of these supplements in improving renal function.

13. Priobiotic Groups creatinine lowered compared to controlled group

The 12-month prospective observation study with a randomized control and open-label design titled Influence of prebiotic and probiotic supplementation on the progression of chronic kidney disease was done by Malleshappa PAVAN, Division of Nephrology, Department of Medicine, Adichunchanagiri Institute of Medical Sciences B. G. Nagara, Karnataka State, India. The experiment provided low protein diet and 3 probiotics tablet per day. Study conclude that Prebiotic and probiotic supplementation along with low protein diet delayed the progression of CKD.

14. Probiotics Reduces Serum C-Reactive Protein

The study searched PubMed-Medline, Web of Science, the Cochrane, and Google Scholar databases (until May 2016) titled Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α.

Another study titled Effects of Probiotics on Inflammation and Uremic Toxins Among Patients on Dialysis: A Systematic Review and Meta-Analysis suggest that  potential beneficial effects of probiotics on inflammation, uremic toxins, and GI Symptoms in ESRD patients and significant reduction in serum C-reactive protein (CRP) from baseline to post-probiotic course (≥ 2 months after treatment) by studying seven clinical trials with 178 ESRD patients.

15. High Dose vitamin C is bad for Kidney creates Oxalosis - The study titled Oxalosis Associated With High-Dose Vitamin C Ingestion in a Peritoneal Dialysis Patient states that  the patient took  4 g of vitamin C per day for several years and examination revealed proliferative retinopathy and calcium oxalate crystals.

We can conclude that probiotics help is restporing gut microbes and effectively help in reducing serum c reactive protein, creatinine, urea, BUN, and help in reducing the chance of ESRD.