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15 Causes of Chronic Kidney Disease in Patients

Chronic kidney disease can be caused by various reasons. What are the major Causes of Chronic Kidney Disease. Here are few major causes of CKD

1. Epstein–Barr virus-associated nephrotic syndrome - New study reveals that there is A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome after EBV infection. Treatment with methylprednisone led to rapid and complete clinical remission. The author also suffered with EBV infection, leading Hodgkin Lymphoma and later IGI Nephropathy.

2. Lymphomas and IgA nephropathy - Article published on 01 August 2001 in Nephrology Dialysis Transplantation titled as Lymphomas and IgA nephropathy authored by Chiara Cherubini, Giovanni Barbera, Salvatore Di Giulio, Andrea Onetti Muda, Tullio Faraggiana mention that the onset of proteinuria and renal failure appears to be subsequent to the development of lymphoma in this patient.

However, the clinical follow‐up suggests that a lymphoproliferative disorder had started at least 1 year before the presentation of kidney involvement but it was misdiagnosed. The relationship between the evident nephropathy and related lymphoma seems to be strong. The remission of renal involvement after chemotherapy in this patient supports this observation. Here is a kidney biopsy report of a patient with HL and IgA Nephropathy.

kidney biopsy report of a patient with HL and IgA Nephropathy

kidney biopsy report of a patient with HL and IgA Nephropathy

IgA nephropathy can be triggered by lymphoma or any other virus infection. Many CKD patients do remember having respiratory infections before getting diagnosed with CKD.

3. Polycystic kidney disease (PKD) and Nephropathy - PKD is a rare genetic disorded where fluid-filled cysts form inside the kidney resulting the in the damage of filters and developing ESRD.

4. Diabetic nephropathy  - Diabetis is a leading cause of ESRD in patients. High levels of blood sugar in the blood will force kidney to filter blood many times. This will damage the small filters as renal pressure and due to overwork.

5. High Salt Foods Induced Hypertension in CKD - When the kidney is damaged, salt increases in the blood level increasing hyper tension. It is always better to keep the sodium take to a minimum to reduce blood pressure. Moderate salt restriction significantly reduces BP and proteinuria/albuminuria in patients with CKD (Stage 1–4).

Causes of Chronic Kidney Disease in Patients

6. Hidden infections - There might be many hidden infections in the body such as yeast, viruses, bacteria, Lyme, etc. Staphylococcus aureus and various Gram-negative organisms produces toxic waste and creates small ulcers in the stomach. These toxic waste end up in blood and thereby creating renal damage. Many of the tested patients with ckd has urinary tract infection and decubitus ulcers. 19 bacterias such as Corynebacterium, Lactobacillus, Gardnerella, Prevotella, Escherichia/Shigella and Enterobacteriaceae were found in the urine samples of CKD patients.

7. Hidden food allergens - Many patients with CKD who were steroid treatment failure were diagnosed with food allergies. In 27 steroid failure cases, a limited diet with exclusion of one or several foods and a complete remission was induced. An oligoantigenic diet was prescribed for 10 days and proteinuria decreased by more than half in nine patients, with complete disappearance in five cases.

8. Celiac disease, IBD, Crohn's disease, Colitis, Ulcers - There are many stomach related diseases than can cause kidney disease. It is always better to test them and see if any of them are contributing to this.

9. Heavy metal toxicity - Arsenic, cadmium, lead, and mercury and other metals can cause renal impairment.

10. Tuberous sclerosis complex (TSC) - Tuberous sclerosis complex is a condition where benign tumors forms in the body. These tumors can be formed in kidney creating nephropathy and renal cystic lesions. TCS and PKD often appear together making it hard to treat. Proper diet and medications can reduce the chances of these tumors.

11. Effect of medicines - Many of the us take different medications in our life time. Some of these medications have so many side effects that are ignored by the medical community. These medications can cause renal impairment and CKD. 5-aminosalicylic acid is used to treat Crohn's disease which can lead someone to renal impairment. Significant decrease in GFR is induced by low-dose ciclosporin therapy in Uveritis patients. Nonsteroidal anti-inflammatory drugs (NSAIDs) have a long history of creating renal damage. Aspirin, ibuprofin are some examples of this.

12. Genes - IgA nephropathy is more common in some families and in certain ethnic groups.

13. Liver diseases - These include cirrhosis, a condition in which scar tissue replaces normal tissue within the liver, and chronic hepatitis B and C infections.

14. Deregulation of Wnt pathway - Activation of wnb pathway is instrumental for tubular repair and regeneration after acute kidney injury. New research is showing the effect of wnt pathway to ckd.

15. Hepatitis A - HAV-associated IgA nephropathy is extremely rare . In this case the patient undergone a spontaneous remission after the treatment for HAV.